Peripheral Neuropathy in Hand Leg – Causes, Symptoms, Treatment


Peripheral neuropathy is a common and most important problem in peripheral nerve cells that is caused by diabetic neuropathy, nutritional deficiency, nerve injury, and demyelination of nerve cells. It is basically found of elderly people even after 50 years or more. It mainly occurs more in postmenopausal women compared to men. In latest scientific research found a wide variety of problem is working behind. So to avoid this disease pretreatment is essential to overcome this disease. There are many kinds of tools to identify the classification of peripheral neuropathy, mononeuropathies, polyneuropathies, multifactorial neuropathies axonal demyelinating that vital factor to treatment of this condition

Causes of Peripheral Neuropathy in Hand Leg

The most important cause Peripheral Neuropathy in Hand Leg in hand and leg muscle are described bellow

  • Diabetic Mellitus, it may type 1 or types 2
  • Over uses and addictions to alcohol
  • Chronic alcoholism in the late stage of life
  • The nutritional deficiencies that are B1, B6, B12, vitamin E
  • Inflammatory conditions such as vasculitis, cellulitis
  • Hypothyroidism or abnormal endocrine system
  • An autoimmune disease that falls into Sjogren syndrome, lupus erythematosus, rheumatoid arthritis
  • Infections (Epstein-Barr virus, Lyme disease, chronic hepatitis
  • The Guillain-Barre syndrome
  • Toxins induce disease (heavy metals, chemicals)
  • Prolong hemotherapy of cancer patients and its related therapy
  • Overuse of antibacterial drugs and some cardiovascular medications
  • Tumors (it may be  secondary to compression or the paraneoplastic syndromes
  • Inherited conditions are familial amyloidosis Charcot-Marie-Tooth disease
  • Trauma/injury
  • Multiple myeloma and its treatments
  • Monoclonal gammopathy of undetermined significance (MGUS)

Symptoms of Peripheral Neuropathy in Hand Leg

The symptoms of Peripheral Neuropathy in Hand Legare described bellow

  • Pain that may be prolonged or acute onset in a long time standing, and sitting
  • Pain paresthesia may be an increase during working, running
  • Pain and paresthesia also increase during traveling on a motorbike for long-distance.
  • Muscle  fatigue may be an increase in working or driving
  • Feeling toresness frequently
  • Muscle spasm and wasting may be found frequently
  • The electrolyte imbalance  in your body may found
  • Feeling tiredness may be found in small working
  • Blood pressure may be increase and gait and posture become abnormal

Diagnosis of Peripheral Neuropathy in Hand Leg

Your doctor may advise you to test to investigate the Peripheral Neuropathy in Hand Leg

  • Complete blood count to investigate the macrocytic anemia, vitamin b12 deficiency, folate deficiency
  • Metabolic Panels disorders such as BMP or CMP along with renal failure, electrolyte imbalance as uremia can also lead to neuropathy and Peripheral Neuropathy in Hand Leg.
  • HbA1c Testing (Diabetes is a common cause of neuropathy
  • Testing for vitamin and mineral deficiencies such as mainly copper, thiamine or vitamin B^, pyridoxine, folate or vitamin B9, vitamin B12, and vitamin E which play important roles in central and peripheral nervous system development and maintenance.
  • Heavy metal toxicities in the industrial area, such as mercury, lead, arsenic are known to cause peripheral nerve toxicities along with CNS disturbances.
  • Test for infectious material that falls into for Lyme disease, Epstein-Barr virus, hepatitis C, HIV, and syphilis
  • Thyroid function testing.
  • Anti-body testing to investigate for specific autoimmune diseases known to cause peripheral neuropathies such as Sjogren syndrome, lupus, rheumatoid arthritis.
  • Nerve conduction velocity test and electromyography (EMG)
  • MRI or CT s  to identify the nerve root compression or nerve-related disease
  • Nerve biopsy
  • Genetic testing for identifying the causes of inherited neuropathies and jhin jhin and obosh bbosh vab
  • Urine Test to investigate the infection, or infectious disease.


  • Radiographs of the joint – Conventional x-ray and radiography is the most widely used imaging modality and allows for the detection of bone fractures, osteoporosis, and abnormal pathologies condition like fracture, osteoporosis, erosions, osteonecrosis, osteoarthritis, or a juxta-articular bone tumor, neoplasm. Characteristic features of neck rheumatoid arthritis, osteoarthritis include marginal osteophytes formation for Obosh Obosh and jhin jhin vab in Leg and Hand, joint space gradually narrowing, subchondral sclerosis formation, and cysts.
  • CT Scan – High contrast CT scan is more effective to diagnose the spinal cord, surrounding muscle, rheumatoid arthritis. Abnormal tendon, ligament, cartilage, muscle and osteophyte, synovial fluid are also found in this test. It also helps to identify the bone tumor, necrosis, spinal stenosis,  abnormal vertebrae condition, etc.
  • MRI – It is called magnetic radical imaging is also helpful to find the bone conditions, abnormal tendon, ligament, cartilage, muscle and osteophyte, synovial fluid. It also helps to identify the bone tumor, necrosis, abnormal joint condition, soft tissue, etc. It is the final stage test to confirm that all joint abnormality.

Treatment of Peripheral Neuropathy in Hand Leg

  • Muscle relaxant – It is important for patients with chronic muscle spasms, wasting, and muscle cramping releasing drugs. The drugs are tolperisone HCL, eperisone, baclofen, dantrolene, etc. The drug increases the blood supply with oxygen and nutrition to the affected joint.
  • Nerve relaxant –  It is basically used to reduce neuropathic pain, inflammation, nerve root encryption, myalgia, neuralgia, and fibromyalgia. Your doctor may prescribe gabapentin, pregabalin, vitamin B1, B6, B12, etc. Major side effects are abdominal pain, nausea- vomiting.
  • Calcium & vitamin D3 – to improve bone health and healing fractures and osteoporosis, osteonecrosis. Your doctor may prescribe to take calcium and vitamin D3 supplementation to prevent thinning of the bone and maintain bone health and muscle pain. In scientific study show that normal men and women needed calcium 1200milligram and vitamin D3 500 milligram.
  • Anticonvulsant drugs – It has gained popularity for neuropathic pain, with gabapentin (Neurontin) and pregabalin (Lyrica) being the most commonly used preparations in spine-related pain, radiating pain, and post-operative PLID. Gabapentin has been shown to be superior to pain killers in alleviating back and leg pain after spinal surgery []. Pregabalin plays an important role in the prevention of pain before and after surgery[].



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